ABL800 FLEX blood gas analyzer
Offering you trusted results and greater operational efficiency
- Reliable results on 18 vital parameters
- Spend less time in front of the analyzer with FLEXQ
- Configured to meet your needs
Reliable, Efficient, Flexible
Amidst pressures to optimize resources and personnel, equip and empower busy laboratory staff with:
- Results you can trust
- Improved workflow
- A flexible partner to meet your needs
"Drop-n-Go" on the FLEXQ
Fully automatic scanning, mixing, and aspiration of blood samples
Easy to operate screen
Intuitive interface with highly responsive tablet-like interaction
Additional clinical insight
Measure up to 18 critical parameters on one sample to support fast diagnosis
Autocheck
Supporting compliance with automatic QC
Parameters measured
Potential of hydrogen
The degree of acidity or alkalinity of any liquid (including blood) is a function of its hydrogen ion concentration [H+], and pH is simply a way of expressing hydrogen ion activity. The relationship between pH and hydrogen ion concentration is described thus:
pH = -log aH+
where aH+ is hydrogen ion activity.
Low pH is associated with acidosis and high pH with alkalosis [1,2].
The pH parameter is measured on these ABL blood gas analyzers:
- CLSI. Blood gas and pH analysis and related measurements; Approved Guidelines. CLSI document CA46-A2, 29, 8. Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2009
- Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook
Partial pressure of carbon dioxide
Carbon dioxide (CO2) is an acidic gas; the amount of CO2 in blood is largely controlled by the rate and depth of breathing or ventilation. pCO2 is the partial pressure of CO2 in blood. It is a measure of the pressure exerted by that small portion (~5 %) of total CO2 that remains in the gaseous state, dissolved in the blood plasma. pCO2 is the respiratory component of acid-base balance and reflects the adequacy of pulmonary ventilation. The severity of ventilator failure as well as the chronicity can be judged by the accompanying changes in acid-base status [1,2].
The pCO2 parameter is measured on these ABL blood gas analyzers:
- Higgins C. Parameters that reflect the carbon dioxide content of blood. www.acutecaretesting.org Oct 2008.
- Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014
Partial pressure of oxygen
The amount of oxygen in blood is controlled by many variables, e.g. ventilation/perfusion. pO2 is the partial pressure of oxygen in a gas phase in equilibrium with the blood. pO2 only reflects a small fraction (1 – 2 %) of total oxygen in blood that is dissolved in blood plasma [1]. The remaining 98 – 99 % of oxygen present in blood is bound to the hemoglobin in the erythrocytes. pO2 primarily reflects the oxygen uptake in the lungs. [2]
The pO2 parameter is measured on these ABL blood gas analyzers:
1. Wettstein R, Wilkins R. Interpretation of blood gases. In: Clinical assessment in respiratory care, 6th ed. St. Louis: Mosby, 2010.
2. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.
Glucose
Glucose, the most abundant carbohydrate in human metabolism, serves as the major intracellular energy source (see lactate). Glucose is derived principally from dietary carbohydrate, but it is also produced – primarily in the liver and kidneys – via the anabolic process of gluconeogenesis, and from the breakdown of glycogen (glycogenolysis). This endogenously produced glucose helps keep blood glucose concentration within normal limits, when dietary-derived glucose is not available, e.g. between meals or during periods of starvation. [1]
The cGlu parameter is measured on these ABL blood gas analyzers:
1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.
Lactate, the anion that results from dissociation of lactic acid, is an intracellular metabolite of glucose. It is produced by skeletal muscle cells, red blood cells (erythrocytes), the brain, and other tissues during anaerobic energy production (glycolysis). Lactate is formed in the intracellular fluid from pyruvate; the reaction is catalyzed by the enzyme lactate dehydrogenase (LDH) [1,2].
1. Robergs RA, Ghiasvand F, Parker D. Biochemistry of exercise-induced metabolic acidosis. Am J Physiol Regul Integr Comp Physiol 2004; 287: R502-16.
2. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.
Creatinine
Creatinine is an endogenous waste product of muscle metabolism, derived from creatine, a molecule of major importance for energy production within muscle cells. Creatinine is removed from the body in urine and its concentration in blood reflects glomerular filtration and thereby kidney function. [1]
The cCrea parameter is measured on these ABL blood gas analyzers:
1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.
Calcium
The calcium ion (Ca2+) is one of the most prevalent cations in the body, where approximately 1 % is present in the extracellular fluid of blood. Ca2+ plays a vital role for bone mineralization and many cellular processes, e.g. contractility of the heart and the skeletal musculature, neuromuscular transmission, hormone secretion and action in various enzymatic reactions such as, e.g. blood coagulation. [1]
The cCa2+ parameter is measured on these ABL blood gas analyzers:
1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.
Chloride
Chloride (Cl-) is the major anion in the extracellular fluid and one of the most important anions in blood. The main function of Cl- is to maintain osmotic pressure, fluid balance, muscular activity, ionic neutrality in plasma, and help elucidate the cause of acid-base disturbances. [1]
The cCl- parameter is measured on these ABL blood gas analyzers:
1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.
Potassium
Potassium (K+) is the major cation in the intracellular fluid, where it has a 25 - 37-fold higher concentration (∼150 mmol/L in tissue cells, ∼105 mmol/L in erythrocytes) than in the extracellular fluid (∼4 mmol/L) [1, 2]. K+ has several vital functions in the body, e.g. regulation of neuromuscular excitability, regulation of heart rhythm, regulation of intracellular and extracellular volume and acid-base status. [3]
The cK+ parameter is measured on these ABL blood gas analyzers:
1. Burtis CA, Ashwood ER, Bruns DE. Tietz textbook of clinical chemistry and molecular diagnostics. 5th ed. St. Louis: Saunders Elsevier, 2012.
2. Engquist A. Fluids/Electrolytes/Nutrition. 1st ed. Copenhagen: Munksgaard, 1985.
3. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.
Sodium
Sodium (Na+) is the dominant cation in the extracellular fluid, where it has a 14-fold higher concentration (∼140 mmol/L) than in the intracellular fluid (∼10 mmol/L). Na+ is a major contributor of the osmolality of the extracellular fluid and its main function is largely in controlling and regulating water balance, and maintaining blood pressure. Na+ is also important for transmitting nerve impulses and activating muscle concretion. [1]
The cNa+ parameter is measured on these ABL blood gas analyzers:
1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.
Carboxyhemoglobin
FCOHb is the fraction of total hemoglobin (ctHb) which is present as carboxyhemoglobin (COHb). By convention the fraction is expressed as a percentage (%).
In the range of 0 – 60 % COHb in arterial (COHb(a)) and venous blood (COHb(v)) is similar, i.e. either venous or arterial blood may be analyzed [1]. In most medical texts FCOHb(a) is referred to as simply COHb. [2]
The COHb parameter is measured on these ABL blood gas analyzers:
1. Lopez DM, Weingarten-Arams JS, Singer LP, Conway EE Jr. Relationship between arterial, mixed venous and internal jugular carboxyhemoglobin concentrations at low, medium and high concentrations in a piglet model of carbon monoxide toxicity. Crit Care Med 2000; 28: 1998-2001.
2. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.
Bilirubin
Bilirubin is the yellow breakdown product of the degradation of the heme group of hemoglobin. It is transported in blood from its site of production – the reticuloendothelial system – to the liver, where it is biotransformed before excretion in bile. Jaundice, the pathological yellow discoloration of skin, is due to abnormal accumulation of bilirubin in the tissues, and is always associated with elevated blood concentration of bilirubin (hyperbilirubinemia). [1]
The ctBil parameter is measured on these ABL blood gas analyzers:
1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.
Total hemoglobin
The concentration of total hemoglobin (ctHb) in blood includes oxyhemoglobin (cO2Hb), deoxyhemoglobin (cHHb), as well as the dysfunctional hemoglobin species that are incapable of binding oxygen:
carboxyhemoglobin (cCOHb) (see COHb), methemoglobin (cMetHb) (see MetHb) and sulfhemoglobin (cSulfHb).
Thus:
ctHb = cO2Hb + cHHb + cCOHb + cMetHb + cSulfHb
The rare sulfHb is not included in the reported c tHb in most oximeters. [1]
The ctHb parameter is measured on these ABL blood gas analyzers:
1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.
Fraction of fetal hemoglobin
FHbF in total hemoglobin in blood. [1]
1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.
Fraction of deoxyhemoglobin
FHHb in total hemoglobin in blood. [1]
1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.
Metahemoglobin
FMetHb is the fraction of total hemoglobin (ctHb) that is present as methemoglobin (MetHb). By convention the fraction is expressed as a percentage (%) [1]. In most medical text boxes MetHb(a) is referred to as simply methemoglobin (MetHb). [2]
The MetHb parameter is measured on these ABL blood gas analyzers:
1. CLSI. Blood gas and pH analysis and related measurements; Approved Guidelines. CLSI document CA46-A2, 29, 8. Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2009.
2. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.
Oxygen saturation
Oxygen saturation (sO2) is the ratio of oxyhemoglobin concentration to concentration of functional hemoglobin (i.e. oxyhemoglobin (O2Hb) and deoxyhemoglobin (HHb) capable of carrying oxygen [1].
The sO2 reflects utilization of the currently available oxygen transport capacity. In arterial blood 98 – 99 % of oxygen is transported in erythrocytes bound to hemoglobin. The remaining 1–2 % of the oxygen transported in blood is dissolved in the blood plasma – this is the portion reported as partial pressure of oxygen (pO2) [2,3].
The sO2 parameter is measured on these ABL blood gas analyzers:
1. CLSI. Blood gas and pH analysis and related measurements; Approved Guidelines. CLSI document CA46-A2, 29, 8. Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2009.
2. Higgins C. Parameters that reflect the carbon dioxide content of blood. www.acutecaretesting.org Oct 2008.
3. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.
Fraction of oxyhemoglobin
FO2Hb in total hemoglobin in blood. [1]
The FO2Hb parameter is measured on these ABL blood gas analyzers:
1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.
The equipment I use in my work must be trustworthy, user-friendly and reliable […] For more than ten years, we’ve been using the ABL800 series from Radiometer. It works very well for us.
- Anna-Karin Ståhlberg, Biomedical Analyst, Clinical Chemistry Laboratory, Halland´s Hospital Halmstad, Sweden
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- Support sample integrity
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Supporting an improved blood gas workflow with efficient automation
Combine your ABL800 FLEX and safePICO syringes with AQURE's FLEXLINK system to utilize 1st Automatic. The connected solution registers patient, operator and sample IDs at the bedside, while FLEXLINK links these data together. An example of how it could expedite your workflow is shown below.
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